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DNASE1
Loading...Anti-DNASE1 Products
- Anti-DNASE1 Immunohistochemistry Kit (VS-0525-XY2038)
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- Species Reactivity: Human
- Target: DNASE1
- Application: IHC
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For Research Use Only. Not For Clinical Use.
This gene encodes a member of the DNase family. This protein is stored in the zymogen granules of the nuclear envelope and functions by cleaving DNA in an endonucleolytic manner. At least six autosomal codominant alleles have been characterized, DNASE1*1 through DNASE1*6, and the sequence of DNASE1*2 represented in this record. Mutations in this gene have been associated with systemic lupus erythematosus (SLE), an autoimmune disease. A recombinant form of this protein is used to treat the one of the symptoms of cystic fibrosis by hydrolyzing the extracellular DNA in sputum and reducing its viscosity. Alternate transcriptional splice variants of this gene have been observed but have not been thoroughly characterized.
Protein class
Disease related genes, Enzymes, Potential drug targets
Predicted location
Intracellular, Secreted (different isoforms)
Single cell type specificity
Cell type enriched (Proximal enterocytes)
Immune cell specificity
Low immune cell specificity
Cell line specificity
Low cell line specificity
Molecular function
Actin-binding, Endonuclease, Hydrolase, Nuclease
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