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DOCK4
This gene is a member of the dedicator of cytokinesis (DOCK) family and encodes a protein with a DHR-1 (CZH-1) domain, a DHR-2 (CZH-2) domain and an SH3 domain. This membrane-associated, cytoplasmic protein functions as a guanine nucleotide exchange factor and is involved in regulation of adherens junctions between cells. Mutations in this gene have been associated with ovarian, prostate, glioma, and colorectal cancers. Alternatively spliced variants which encode different protein isoforms have been described, but only one has been fully characterized. [provided by RefSeq, Jul 2008]
Protein class
Plasma proteins
Predicted location
Intracellular
Single cell type specificity
Group enriched (Microglial cells, Oligodendrocytes, Astrocytes, Oligodendrocyte precursor cells, Excitatory neurons)
Immune cell specificity
Immune cell enriched (neutrophil)
Cell line specificity
Cell line enhanced (hTEC/SVTERT24-B, HUVEC TERT2, TIME)
Interaction
Interacts with nucleotide-free Rap1; functions as a guanine nucleotide exchange factor (GEF) for Rap1 (PubMed:12628187). Interacts (via DOCKER domain) with RAC1; functions as a guanine nucleotide exchange factor (GEF) for RAC1 (PubMed:16464467). Interacts with the SH3 domain of CRK (PubMed:12628187). Interacts with FASLG (PubMed:19807924). Interacts with ELMO2 and EPHA2; mediates activation of RAC1 by EPHA2 (PubMed:20679435). Interacts with USH1C (via PDZ 1 domain) (PubMed:16464467).
Molecular function
Guanine-nucleotide releasing factor
More Types Infomation
- Rabbit Anti-DOCK4 Polyclonal Antibody (MRO-1820-CN) (MRO-1820-CN)
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- Species Reactivity: Human, Mouse, Rat
- Type: Rabbit IgG
- Application: WB, IF, IHC
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- Species Reactivity: Human
- Application: IHC-P, WB
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For Research Use Only. Not For Clinical Use.