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DOCK7
The protein encoded by this gene is a guanine nucleotide exchange factor (GEF) that plays a role in axon formation and neuronal polarization. The encoded protein displays GEF activity toward RAC1 and RAC3 Rho small GTPases but not toward CDC42. Several transcript variants encoding different isoforms have been found for this gene.
Protein class
Disease related genes, Human disease related genes
Predicted location
Intracellular
Single cell type specificity
Cell type enhanced (Astrocytes, Inhibitory neurons)
Immune cell specificity
Immune cell enhanced (myeloid DC)
Cell line specificity
Low cell line specificity
Interaction
Component of the DOCK7-induced septin displacement/DISP complex, at least composed of DOCK7, LRCH3 and MYO6 (PubMed:29467281). Interacts with TSC1. Interacts with nucleotide-free RAC1 and RAC3. Interacts with TACC3 and CRY1 (By similarity). Interacts with NOD2 (PubMed:27812135).
Molecular function
Developmental protein, Guanine-nucleotide releasing factor
More Types Infomation
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- Species Reactivity: Human
- Application: Dot, WB
- Recombinant Human Anti-Dock7 Soluble TCR (IA4) (C-Cys) (VS-0622-YF3846)
-
- Species Reactivity: Human
- Epitope: FLNDLLSVM
- MHC: HLA-DRB5
- Recombinant Human Anti-Dock7 Soluble TCR (GH4) (C-Cys) (VS-0622-YF3845)
-
- Species Reactivity: Human
- Epitope: FLNDLLSVM
- MHC: HLA-DRB5
- Recombinant Human Anti-Dock7 Soluble TCR (BD6) (C-Cys) (VS-0622-YF3844)
-
- Species Reactivity: Human
- Epitope: FLNDLLSVM
- MHC: HLA-DRB5
- Recombinant Human Anti-Dock7 Soluble TCR (AD10) (C-Cys) (VS-0622-YF3843)
-
- Species Reactivity: Human
- Epitope: FLNDLLSVM
- MHC: HLA-DRB5
- Recombinant Human Anti-Dock7 Soluble TCR (IA4) (ZIP-Fos/ZIP-Jun) (VS-0622-YF1138)
-
- Species Reactivity: Human
- Epitope: FLNDLLSVM
- MHC: HLA-DRB5
- Recombinant Human Anti-Dock7 Soluble TCR (GH4) (ZIP-Fos/ZIP-Jun) (VS-0622-YF1137)
-
- Species Reactivity: Human
- Epitope: FLNDLLSVM
- MHC: HLA-DRB5
- Recombinant Human Anti-Dock7 Soluble TCR (BD6) (ZIP-Fos/ZIP-Jun) (VS-0622-YF1136)
-
- Species Reactivity: Human
- Epitope: FLNDLLSVM
- MHC: HLA-DRB5
- Recombinant Human Anti-Dock7 Soluble TCR (IA4) (KIH) (VS-0622-YF6554)
-
- Species Reactivity: Human
- Epitope: FLNDLLSVM
- MHC: HLA-DRB5
- Recombinant Human Anti-Dock7 Soluble TCR (AD10) (ZIP-Fos/ZIP-Jun) (VS-0622-YF1135)
-
- Species Reactivity: Human
- Epitope: FLNDLLSVM
- MHC: HLA-DRB5
- Human Anti-Dock7 Recombinant Soluble TCR (IA4) (scTCR-385ZP-S(P))
-
- Species Reactivity: Human
- Epitope: FLNDLLSVM
- MHC: HLA-DRB5
- Human Anti-Dock7 Recombinant Soluble TCR (GH4) (scTCR-384ZP-S(P))
-
- Species Reactivity: Human
- Epitope: FLNDLLSVM
- MHC: HLA-DRB5
- Human Anti-Dock7 Recombinant Soluble TCR (BD6) (scTCR-383ZP-S(P))
-
- Species Reactivity: Human
- Epitope: FLNDLLSVM
- MHC: HLA-DRB5
- Human Anti-Dock7 Recombinant Soluble TCR (AD10) (scTCR-382ZP-S(P))
-
- Species Reactivity: Human
- Epitope: FLNDLLSVM
- MHC: HLA-DRB5
- Human Anti-DOCK7 Recombinant Soluble TCR (clone IA4) (scTCR-0325YC-S(P))
-
- Epitope: FLNDLLSVL
- MHC: HLA-A2
- Human Anti-DOCK7 Recombinant Soluble TCR (clone GH4) (scTCR-0324YC-S(P))
-
- Epitope: FLNDLLSVL
- MHC: HLA-A2
- Human Anti-DOCK7 Recombinant Soluble TCR (clone BD6) (scTCR-0323YC-S(P))
-
- Epitope: FLNDLLSVL
- MHC: HLA-A2
- Human Anti-DOCK7 Recombinant Soluble TCR (clone AD10) (scTCR-0322YC-S(P))
-
- Epitope: FLNDLLSVL
- MHC: HLA-A2
- Recombinant Human Anti-Dock7 Soluble TCR (GH4) (KIH) (VS-0622-YF6553)
-
- Species Reactivity: Human
- Epitope: FLNDLLSVM
- MHC: HLA-DRB5
- Recombinant Human Anti-Dock7 Soluble TCR (BD6) (KIH) (VS-0622-YF6552)
-
- Species Reactivity: Human
- Epitope: FLNDLLSVM
- MHC: HLA-DRB5
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For Research Use Only. Not For Clinical Use.