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DPP4
Enables several functions, including collagen binding activity; dipeptidyl-peptidase activity; and identical protein binding activity. Involved in several processes, including B-1a B cell differentiation; proteolysis; and regulation of lymphocyte mediated immunity. Located in several cellular components, including Golgi apparatus; cell surface; and endoplasmic reticulum. Human ortholog(s) of this gene implicated in Middle East respiratory syndrome and type 2 diabetes mellitus. Orthologous to human DPP4 (dipeptidyl peptidase 4).
Protein class
CD markers, Enzymes, FDA approved drug targets, Plasma proteins
Predicted location
Intracellular, Secreted (different isoforms)
Single cell type specificity
Cell type enhanced (Proximal enterocytes, Syncytiotrophoblasts, Cytotrophoblasts, Proximal tubular cells)
Immune cell specificity
Immune cell enhanced (MAIT T-cell)
Cell line specificity
Cell line enhanced (ASC diff, ASC TERT1, BJ hTERT+, RPTEC TERT1)
Interaction
Monomer. Homodimer (PubMed:12832764, PubMed:15448155, PubMed:17287217, PubMed:12646248, PubMed:12483204, PubMed:12906826). Heterodimer with Seprase (FAP) (PubMed:16651416). Requires homodimerization for optimal dipeptidyl peptidase activity and T-cell costimulation. Found in a membrane raft complex, at least composed of BCL10, CARD11, DPP4 and IKBKB (PubMed:17287217). Associates with collagen (PubMed:8526932). Interacts with PTPRC; the interaction is enhanced in an interleukin-12-dependent manner in activated lymphocytes (PubMed:12676959). Interacts (via extracellular domain) with ADA; does not inhibit its dipeptidyl peptidase activity (PubMed:15016824, PubMed:10951221, PubMed:14691230, PubMed:7907293, PubMed:8101391). Interacts with CAV1 (via the N-terminus); the interaction is direct (PubMed:17287217). Interacts (via cytoplasmic tail) with CARD11 (via PDZ domain); its homodimerization is necessary for interaction with CARD11 (PubMed:17287217). Interacts with IGF2R; the interaction is direct (PubMed:10900005). Interacts with GPC3 (PubMed:17549790). Interacts with human coronavirus-EMC spike protein and acts as a receptor for this virus (PubMed:23486063). (Microbial infection) Interacts with MERS coronavirus/MERS-CoV spike protein.
Molecular function
Aminopeptidase, Hydrolase, Protease, Receptor, Serine protease
More Types Infomation
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- Species Reactivity: Human
- Type: Mouse antibody
- Application: FC, FuncS, IHC-Fr, IP
- Rabbit Anti-DPP4 Recombinant Antibody (clone JM11-42) (MRO-0290-CN)
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- Species Reactivity: Human, Mouse, Rat
- Type: Rabbit IgG
- Application: WB, IF, IHC, FC
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- Species Reactivity: Rat
- Type: Mouse scFv
- Application: WB, FuncS
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- Species Reactivity: Rat
- Type: Mouse Fab
- Application: WB, FuncS
-
- Species Reactivity: Rat
- Type: Mouse Fab
- Application: ELISA, WB, FuncS
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- Species Reactivity: Rat
- Type: Mouse IgG
- Application: WB, FuncS
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- Species Reactivity: Rat
- Type: Mouse IgG
- Application: ELISA, WB, FuncS
-
- Derivation: Phage display library
- Species Reactivity: Human
- Type: Rabbit IgG
- Application: WB
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- Species Reactivity: Rat
- Type: Mouse scFv
- Application: ELISA, WB, FuncS
- Mouse Anti-DPP4 Recombinant Antibody (clone OX61) (FAMAB-1627CQ)
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- Species Reactivity: Rat
- Type: Mouse IgG2a
- Application: ICC, IP, RIA, WB, FC, IF, IHC
- Mouse Anti-DPP4 Antibody (clone OX61), mRNA (FAMAB-1627CQ-mRNA)
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- Species Reactivity: Rat
- Mouse Anti-DPP4 Antibody (clone MK-0431), mRNA (PABL-690-mRNA)
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- Species Reactivity: Rat
- Human Anti-DPP4 Recombinant Antibody; scFv Fragment (HPAB-3029LY-S(P)) (HPAB-3029LY-S(P))
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- Species Reactivity: Human
- Type: Human scFv
- Application: FC
- Human Anti-DPP4 Recombinant Antibody; scFv Fragment (HPAB-0214-YC-S(P)) (HPAB-0214-YC-S(P))
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- Derivation: Humanized
- Species Reactivity: Human
- Type: Humanized scFv
- Application: ELISA
- Mouse Anti-DPP4 Recombinant Antibody; scFv Fragment (HPAB-0213-YC-S(P)) (HPAB-0213-YC-S(P))
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- Species Reactivity: Human, Porcine
- Type: Mouse scFv
- Application: FC, FuncS
- Human Anti-DPP4 Recombinant Antibody; Fab Fragment (HPAB-3029LY-F(E)) (HPAB-3029LY-F(E))
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- Species Reactivity: Human
- Type: Human Fab
- Application: FC
- Human Anti-DPP4 Recombinant Antibody; scFv Fragment (HPAB-0217-YC-S(P)) (HPAB-0217-YC-S(P))
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- Derivation: Humanized
- Species Reactivity: Human
- Type: Humanized scFv
- Application: ELISA
- Human Anti-DPP4 Recombinant Antibody; scFv Fragment (HPAB-0216-YC-S(P)) (HPAB-0216-YC-S(P))
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- Derivation: Humanized
- Species Reactivity: Human
- Type: Humanized scFv
- Application: ELISA
- Human Anti-DPP4 Recombinant Antibody; scFv Fragment (HPAB-0215-YC-S(P)) (HPAB-0215-YC-S(P))
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- Derivation: Humanized
- Species Reactivity: Human
- Type: Humanized scFv
- Application: ELISA
- Human Anti-DPP4 Recombinant Antibody; Fab Fragment (HPAB-0216-YC-F(E)) (HPAB-0216-YC-F(E))
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- Derivation: Humanized
- Species Reactivity: Human
- Type: Humanized Fab
- Application: ELISA
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For Research Use Only. Not For Clinical Use.