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DSC1

The protein encoded by this gene is a calcium-dependent glycoprotein that is a member of the desmocollin subfamily of the cadherin superfamily. These desmosomal family members, along with the desmogleins, are found primarily in epithelial cells where they constitute the adhesive proteins of the desmosome cell-cell junction and are required for cell adhesion and desmosome formation. A subtype of IgA pemphigus, a life-threatening autoimmune disease, is characterized by the presence of autoantibodies that target the encoded protein. The desmosomal family members are arranged in two clusters on chromosome 18. Alternative splicing of this gene results in multiple transcript variants. At least one of these variants encodes a preproprotein that is proteolytically processed to generate the mature protein.
Protein class

Plasma proteins

Predicted location

Membrane

Single cell type specificity

Cell type enriched (Suprabasal keratinocytes)

Immune cell specificity

Group enriched (naive CD4 T-cell, naive CD8 T-cell)

Cell line specificity

Not detected

Interaction

Binds to JUP/plakoglobin.

More Types Infomation

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For Research Use Only. Not For Clinical Use.

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