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The protein encoded by this gene is a calcium-dependent glycoprotein that is a member of the desmocollin subfamily of the cadherin superfamily. These desmosomal family members, along with the desmogleins, are found primarily in epithelial cells where they constitute the adhesive proteins of the desmosome cell-cell junction and are required for cell adhesion and desmosome formation. The desmosomal family members are arranged in two clusters on chromosome 18, occupying less than 650 kb combined. Mutations in this gene are a cause of hypotrichosis and recurrent skin vesicles disorder. The protein can act as an autoantigen in pemphigus diseases, and it is also considered to be a biomarker for some cancers. Alternative splicing of this gene results in multiple transcript variants.

Species Reactivity:
Human
Type:
Mouse antibody
Application:
IHC-P, WB
Derivation:
Mouse
Species Reactivity:
Human
Type:
IgG
Application:
ELISA, WB, FC, FuncS
Derivation:
Mouse
Species Reactivity:
Human
Type:
Fab
Application:
ELISA, WB, FuncS
Derivation:
Mouse
Species Reactivity:
Human
Type:
scFv
Application:
WB, FC, FuncS
Derivation:
Phage display library screening
Species Reactivity:
Human
Type:
IgG
Application:
WB, ICC, FC
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Creative Biolabs is the leading custom service provider that has extensive experience in various antibody production and engineering fields. Our service portfolio includes mouse and rat monoclonal antibody production ...

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