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EDA

The protein encoded by this gene is a type II membrane protein that can be cleaved by furin to produce a secreted form. The encoded protein, which belongs to the tumor necrosis factor family, acts as a homotrimer and may be involved in cell-cell signaling during the development of ectodermal organs. Defects in this gene are a cause of ectodermal dysplasia, anhidrotic, which is also known as X-linked hypohidrotic ectodermal dysplasia. Several transcript variants encoding many different isoforms have been found for this gene.
Protein class

Disease related genes, Human disease related genes

Predicted location

Intracellular, Membrane, Secreted (different isoforms)

Single cell type specificity

Cell type enhanced (Microglial cells, Oligodendrocytes, Oligodendrocyte precursor cells)

Immune cell specificity

Immune cell enhanced (MAIT T-cell, intermediate monocyte)

Cell line specificity

Cell line enhanced (EFO-21, Hep G2, OE19, RPMI-8226)

Interaction

Homotrimer. The homotrimers may then dimerize and form higher-order oligomers.

Molecular function

Developmental protein

More Types Infomation
    • Target: extra domains A (EDA)
    • Linker: Disulfide-linker
    • Drug: DM1 (N2'-Deacetyl-N2'-(3-mercapto-1-oxopropyl)maytansine)

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