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EEF2K
This gene encodes a highly conserved protein kinase in the calmodulin-mediated signaling pathway that links activation of cell surface receptors to cell division. This kinase is involved in the regulation of protein synthesis. It phosphorylates eukaryotic elongation factor 2 (EEF2) and thus inhibits the EEF2 function. The activity of this kinase is increased in many cancers and may be a valid target for anti-cancer treatment.
Protein class
Enzymes
Predicted location
Intracellular
Single cell type specificity
Cell type enhanced (Late spermatids, Bipolar cells)
Immune cell specificity
Not detected in immune cells
Cell line specificity
Cell line enhanced (HaCaT, HL-60, HMC-1, NB-4)
Interaction
Monomer or homodimer (Probable). Interacts with Calmodulin/CALM1; this interaction is strictly required for phosphorylation activity (PubMed:11015200).
Molecular function
Calmodulin-binding, Kinase, Serine/threonine-protein kinase, Transferase
More Types Infomation
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- Derivation: Mouse
- Species Reactivity: Human
- Type: Mouse IgG1, κ
- Application: WB, ELISA, IF, IHC, IP
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- Derivation: Phage display library
- Species Reactivity: Human
- Type: Rabbit IgG
- Application: WB, IP
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For Research Use Only. Not For Clinical Use.