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EGR2
The protein encoded by this gene is a transcription factor with three tandem C2H2-type zinc fingers. Defects in this gene are associated with Charcot-Marie-Tooth disease type 1D (CMT1D), Charcot-Marie-Tooth disease type 4E (CMT4E), and with Dejerine-Sottas syndrome (DSS). Multiple transcript variants encoding two different isoforms have been found for this gene.
Protein class
Disease related genes, Human disease related genes, Transcription factors
Predicted location
Intracellular
Single cell type specificity
Cell type enhanced (Enteroendocrine cells, Breast myoepithelial cells, Breast glandular cells)
Immune cell specificity
Immune cell enhanced (intermediate monocyte, non-classical monocyte)
Cell line specificity
Cell line enriched (U-87 MG)
Interaction
Interacts with HCFC1 (PubMed:14532282). Interacts with WWP2 (PubMed:19651900). Interacts with UBC9 (PubMed:21836637). Interacts with CITED1 (By similarity). Interacts (via phosphorylated form) with SFN (By similarity).
Molecular function
Activator, DNA-binding, Transferase
More Types Infomation
- Rabbit Anti-EGR2 Recombinant Antibody (clone JG78-39) (MRO-0525-CN)
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- Species Reactivity: Human, Mouse, Rat
- Type: Rabbit IgG
- Application: WB, FC
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- Derivation: Mouse
- Species Reactivity: Human
- Type: Mouse IgG1
- Application: WB, ICC, IF, IHC
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- Derivation: Phage display library
- Species Reactivity: Human
- Type: Rabbit IgG
- Application: WB, FC
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For Research Use Only. Not For Clinical Use.