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EIF2AK1
EIF2AK1 (Eukaryotic Translation Initiation Factor 2 Alpha Kinase 1) is a Protein Coding gene. The protein encoded by this gene acts at the level of translation initiation to downregulate protein synthesis in response to stress. The encoded protein is a kinase that can be inactivated by hemin. Diseases associated with EIF2AK1 include Leukoencephalopathy, Motor Delay, Spasticity, And Dysarthria Syndrome and Leukodystrophy, Hypomyelinating, 17.
Protein class
Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets
Predicted location
Intracellular
Single cell type specificity
Group enriched (Erythroid cells, Syncytiotrophoblasts, Cytotrophoblasts)
Immune cell specificity
Low immune cell specificity
Cell line specificity
Low cell line specificity
Interaction
Synthesized in an inactive form that binds to the N-terminal domain of CDC37 (PubMed:11036079). Has to be associated with a multiprotein complex containing Hsp90, CDC37 and PPP5C for maturation and activation by autophosphorylation (PubMed:11036079). The phosphatase PPP5C modulates this activation (PubMed:11036079). Homodimer; homodimerizes in presence of heme, forming a disulfide-linked inactive homodimer (By similarity). Interacts with DELE1; binds to the processed form of DELE1 (S-DELE1) in response to mitochondrial stress, leading to activate its protein kinase activity and trigger the integrated stress response (ISR) (PubMed:32132706, PubMed:32132707).
Molecular function
Kinase, Protein synthesis inhibitor, Serine/threonine-protein kinase, Transferase
More Types Infomation
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- Derivation: Phage display library
- Species Reactivity: Mouse, Rat, Human
- Type: Rabbit IgG
- Application: WB, IHC-P, ICC, IF
- Mouse Anti-EIF2AK1 Recombinant Antibody (VS-0823-LC6) (VS-0823-LC6)
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- Species Reactivity: Human
- Type: Mouse IgG1
- Application: WB, IHC, ELISA
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For Research Use Only. Not For Clinical Use.