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EIF3A
EIF3A (Eukaryotic Translation Initiation Factor 3 Subunit A) is a Protein Coding gene. Diseases associated with EIF3A include Bardet-Biedl Syndrome. Among its related pathways are Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S and Viral mRNA Translation. Gene Ontology (GO) annotations related to this gene include translation initiation factor activity.
Predicted location
Intracellular
Single cell type specificity
Low cell type specificity
Immune cell specificity
Low immune cell specificity
Cell line specificity
Low cell line specificity
Interaction
Interacts with EIF4G1 (By similarity). Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is composed of 13 subunits: EIF3A, EIF3B, EIF3C, EIF3D, EIF3E, EIF3F, EIF3G, EIF3H, EIF3I, EIF3J, EIF3K, EIF3L and EIF3M. The eIF-3 complex appears to include 3 stable modules: module A is composed of EIF3A, EIF3B, EIF3G and EIF3I; module B is composed of EIF3F, EIF3H, and EIF3M; and module C is composed of EIF3C, EIF3D, EIF3E, EIF3L and EIF3K. EIF3C of module C binds EIF3B of module A and EIF3H of module B, thereby linking the three modules. EIF3J is a labile subunit that binds to the eIF-3 complex via EIF3B. The eIF-3 complex interacts with RPS6KB1 under conditions of nutrient depletion. Mitogenic stimulation leads to binding and activation of a complex composed of MTOR and RPTOR, leading to phosphorylation and release of RPS6KB1 and binding of EIF4B to eIF-3. Also interacts with KRT7 and PIWIL2.
Molecular function
Initiation factor, RNA-binding
More Types Infomation
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- Derivation: Phage display library
- Species Reactivity: Human
- Type: Rabbit IgG
- Application: WB, IHC, ICC, FC
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- Derivation: Mouse
- Species Reactivity: Human
- Type: Mouse IgG2b, κ
- Application: WB, ELISA, IF, IHC, IP
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- Species Reactivity: Human, Mouse, Rat
- Type: Rabbit IgG
- Application: WB, IHC-P, IF
- Human Anti-EIF3A Recombinant Antibody; Fab Fragment (HPAB-2215LY-F(E)) (HPAB-2215LY-F(E))
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- Species Reactivity: Human
- Type: Human Fab
- Application: ELISA, WB, RIA, FC, IP, IHC
- Human Anti-EIF3A Recombinant Antibody (HPAB-2215LY) (HPAB-2215LY)
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- Species Reactivity: Human
- Type: Human IgG
- Application: ELISA, WB, RIA, FC, IP, IHC
- Human Anti-EIF3A Recombinant Antibody; scFv Fragment (HPAB-2215LY-S(P)) (HPAB-2215LY-S(P))
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- Species Reactivity: Human
- Type: Human scFv
- Application: ELISA, WB, RIA, FC, IP, IHC
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For Research Use Only. Not For Clinical Use.