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EOMES
This gene belongs to the TBR1 (T-box brain protein 1) sub-family of T-box genes that share the common DNA-binding T-box domain. The encoded protein is a transcription factor which is crucial for embryonic development of mesoderm and the central nervous system in vertebrates. The protein may also be necessary for the differentiation of effector CD8+ T cells which are involved in defense against viral infections. A similar gene disrupted in mice is shown to be essential during trophoblast development and gastrulation. Alternative splicing results in multiple transcript variants.
Protein class
Disease related genes, Human disease related genes, Transcription factors
Predicted location
Intracellular
Single cell type specificity
Cell type enhanced (NK-cells, dendritic cells, T-cells, Erythroid cells)
Immune cell specificity
Group enriched (NK-cell, MAIT T-cell, memory CD8 T-cell, gdT-cell, naive CD8 T-cell)
Cell line specificity
Cell line enhanced (HDLM-2, JURKAT, SCLC-21H)
Molecular function
Activator, Developmental protein, DNA-binding
More Types Infomation
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- Derivation: Mouse
- Species Reactivity: Human
- Type: Mouse IgG2a, κ
- Application: WB, IP, ELISA
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For Research Use Only. Not For Clinical Use.