Cancer-related genes, Disease related genes, Human disease related genes, Plasma proteins, Transcription factors
Intracellular
Cell type enhanced (Adipocytes, Hepatic stellate cells, Endothelial cells, Syncytiotrophoblasts)
Group enriched (basophil, eosinophil)
Cell line enhanced (BEWO, BJ hTERT+, HHSteC, RT4, TIME, U-138 MG)
Interacts with HIF3A (By similarity). Efficient DNA binding requires dimerization with another bHLH protein. Heterodimerizes with ARNT; heterodimer binds to core DNA sequence 5'-TACGTG-3' within the hypoxia response element (HRE) of target gene promoters (PubMed:16181639). Interacts with CREBBP (By similarity). Interacts with EGLN1. Interacts with VHL (PubMed:19208626). (Microbial infection) Interacts with Kaposi's sarcoma-associated herpesvirus/HHV-8 protein ORF34; this interaction results in increased stability of EPAS1 and thus activation of its transcriptional activity.
Activator, Developmental protein, DNA-binding
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For Research Use Only. Not For Clinical Use.