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EPHB2
This gene encodes a member of the Eph receptor family of receptor tyrosine kinase transmembrane glycoproteins. These receptors are composed of an N-terminal glycosylated ligand-binding domain, a transmembrane region and an intracellular kinase domain. They bind ligands called ephrins and are involved in diverse cellular processes including motility, division, and differentiation. A distinguishing characteristic of Eph-ephrin signaling is that both receptors and ligands are competent to transduce a signaling cascade, resulting in bidirectional signaling. This protein belongs to a subgroup of the Eph receptors called EphB. Proteins of this subgroup are distinguished from other members of the family by sequence homology and preferential binding affinity for membrane-bound ephrin-B ligands. Allelic variants are associated with prostate and brain cancer susceptibility. Alternative splicing results in multiple transcript variants.
Protein class
Cancer-related genes, Disease related genes, Enzymes, Metabolic proteins, Plasma proteins, Potential drug targets
Predicted location
Intracellular, Membrane (different isoforms)
Single cell type specificity
Cell type enhanced (Undifferentiated cells, Oligodendrocytes, Pancreatic endocrine cells, Intestinal goblet cells, Enteroendocrine cells, Ductal cells)
Immune cell specificity
Not detected in immune cells
Cell line specificity
Cell line enhanced (GAMG, HUVEC TERT2, TIME, U-251 MG)
Interaction
Heterotetramer upon binding of the ligand (By similarity). The heterotetramer is composed of an ephrin dimer and a receptor dimer (PubMed:17897949). Interacts (via PDZ-binding motif) with GRIP1 and PICK1 (via PDZ domain) (By similarity). Interacts with ARHGEF15; mediates ARHGEF15 phosphorylation, ubiquitination and degradation by the proteasome (By similarity). Interacts with AQP1; involved in endolymph production in the inner ear (By similarity). Interacts with SPSB1 and SPSB4 (PubMed:28931592). The phosphorylated form interacts with RASA1 (via SH2 domain 1) (By similarity). Interacts with EFNA5 (By similarity). Interacts with SH2D3C (By similarity).
Molecular function
Developmental protein, Kinase, Receptor, Transferase, Tyrosine-protein kinase
More Types Infomation
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- Species Reactivity: Human
- Application: WB
- Mouse Anti-EPHB2 Recombinant Antibody; Fab Fragment (HPAB-0292-CN-F(E)) (HPAB-0292-CN-F(E))
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- Species Reactivity: Human
- Type: Mouse Fab
- Application: ELISA, WB, FC, IHC, IF, IP
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- Derivation: Mouse
- Species Reactivity: Human
- Type: Mouse IgG1
- Application: WB, IHC, FC
- Mouse Anti-EPHB2 Recombinant Antibody (HPAB-0292-CN) (HPAB-0292-CN)
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- Species Reactivity: Human
- Type: Mouse IgG1
- Application: ELISA, WB, FC, IHC, IF, IP
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- Species Reactivity: Human
- Type: Mouse IgG2b
- Application: ELISA, WB, ICC
- Anti-EphB2R (clone 2H9)-BMPEO-DM1 ADC (ADC-187CL)
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- Target: EphB2R
- Linker: BMPEO (bis-maleimido-trioxyethylene glycol)
- Drug: DM1 (N2'-Deacetyl-N2'-(3-mercapto-1-oxopropyl)maytansine)
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- Species Reactivity: Human
- Type: Mouse IgG
- Application: WB, IF, ELISA
- Mouse Anti-EPHB2 Recombinant Antibody; scFv Fragment (HPAB-0292-CN-S(P)) (HPAB-0292-CN-S(P))
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- Species Reactivity: Human
- Type: Mouse scFv
- Application: ELISA, WB, FC, IHC, IF, IP
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For Research Use Only. Not For Clinical Use.