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EZR
The cytoplasmic peripheral membrane protein encoded by this gene functions as a protein-tyrosine kinase substrate in microvilli. As a member of the ERM protein family, this protein serves as an intermediate between the plasma membrane and the actin cytoskeleton. This protein plays a key role in cell surface structure adhesion, migration and organization, and it has been implicated in various human cancers. A pseudogene located on chromosome 3 has been identified for this gene. Alternatively spliced variants have also been described for this gene. [provided by RefSeq, Jul 2008]
Protein class
Cancer-related genes, Plasma proteins
Predicted location
Intracellular
Single cell type specificity
Low cell type specificity
Immune cell specificity
Low immune cell specificity
Cell line specificity
Low cell line specificity
Interaction
Monomer. Homodimer (PubMed:27364155). Interacts with PALS1 and SLC9A3R2. Found in a complex with EZR, PODXL and SLC9A3R2 (By similarity). Interacts with MCC, PLEKHG6, PODXL, SCYL3/PACE1, SLC9A3R1 and TMEM8B (PubMed:9314537, PubMed:12651155, PubMed:15498789, PubMed:17616675, PubMed:17881735, PubMed:19555689). Interacts (when phosphorylated) with FES/FPS (PubMed:18046454). Interacts with dimeric S100P, the interaction may be activating through unmasking of F-actin binding sites (PubMed:12808036, PubMed:19111582). Identified in complexes that contain VIM, EZR, AHNAK, BFSP1, BFSP2, ANK2, PLEC, PRX and spectrin (By similarity). Detected in a complex composed of at least EZR, AHNAK, PPL and PRX (By similarity). Interacts with PDPN (via cytoplasmic domain); activates RHOA and promotes epithelial-mesenchymal transition (PubMed:17046996). Interacts with SPN/CD43 cytoplasmic tail, CD44 and ICAM2 (By similarity).
More Types Infomation
- Mouse Anti-EZR Recombinant Antibody (clone CBE227) (MOB-243YJL)
-
- Species Reactivity: Human
- Type: Mouse IgG1
- Application: WB, IP
- Mouse Anti-EZR Recombinant Antibody (clone SAIC-37C-23) (FAMAB-1132CQ)
-
- Species Reactivity: Human
- Type: Mouse IgG1
- Application: Immuno-MRM, WB
-
- Derivation: Phage display library
- Species Reactivity: Human
- Type: Rabbit IgG
- Application: ICC, WB
-
- Species Reactivity: Human
- Application: ELISA, WB
- Mouse Anti-EZR Antibody (clone SAIC-37C-23), mRNA (FAMAB-1132CQ-mRNA)
-
- Species Reactivity: Human
- Rabbit Anti-EZR Recombinant Antibody (clone JM10-65) (MRO-0559-CN)
-
- Species Reactivity: Human
- Type: Rabbit IgG
- Application: WB, IHC
-
- Species Reactivity: Human
- Type: Rabbit IgG
- Application: WB, IHC-P
-
- Species Reactivity: Human, Mouse, Rat, Hamster
- Type: Rabbit IgG
- Application: WB, IHC-P, IP
-
- Derivation: Mouse
- Species Reactivity: Human, Mouse, Monkey
- Type: Mouse IgG1
- Application: WB, ICC, FC
-
- Derivation: Mouse
- Species Reactivity: Human
- Type: Mouse IgG1
- Application: WB, IHC, ICC, FC, ELISA
-
- Derivation: Mouse
- Species Reactivity: Human, Mouse, Rat
- Type: Mouse IgG1
- Application: WB
-
- Derivation: Rabbit
- Species Reactivity: Human
- Type: Rabbit IgG
- Application: ELISA, IHC
-
- Species Reactivity: Human
- Type: Mouse IgG1
- Application: ELISA, WB, ICC, FC
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