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FASN

Engineered Antibody MHC
The enzyme encoded by this gene is a multifunctional protein. Its main function is to catalyze the synthesis of palmitate from acetyl-CoA and malonyl-CoA, in the presence of NADPH, into long-chain saturated fatty acids. In some cancer cell lines, this protein has been found to be fused with estrogen receptor-alpha (ER-alpha), in which the N-terminus of FAS is fused in-frame with the C-terminus of ER-alpha.
Protein class

Cancer-related genes, Enzymes, FDA approved drug targets, Metabolic proteins, Plasma proteins

Predicted location

Intracellular

Single cell type specificity

Cell type enhanced (Breast glandular cells, Hepatocytes, Breast myoepithelial cells, Alveolar cells type 2)

Immune cell specificity

Not detected in immune cells

Cell line specificity

Cell line enhanced (SK-BR-3)

Interaction

Homodimer which is arranged in a head to tail fashion (PubMed:17618296, PubMed:18022563, Ref.34). Interacts with CEACAM1; this interaction is insulin and phosphorylation-dependent; reduces fatty-acid synthase activity.

Molecular function

Hydrolase, Lyase, Multifunctional enzyme, Oxidoreductase, Transferase

More Types Infomation

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For Research Use Only. Not For Clinical Use.

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