Disease related genes, Human disease related genes
Intracellular
Cell type enhanced (Erythroid cells, Late spermatids)
Low immune cell specificity
Low cell line specificity
Part of the SCF (SKP1-CUL1-F-box) E3 ubiquitin-protein ligase complex SCF(FBXO7) formed of CUL1, SKP1, RBX1 and FBXO7. Interacts via its C-terminal proline-rich region with DLGAP5. Interacts with BIRC2. Interacts with CDK6 and promotes its interaction with D-type cyclin. Interacts with PSMF1. [Isoform 1]: Interacts (via the N-terminal Ubl domain) with PRKN (PubMed:23933751). Interact (via N-terminal region) with PINK1 (PubMed:23933751). [Isoform 2]: Interact (via N-terminal region) with PINK1.
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For Research Use Only. Not For Clinical Use.