Cancer-related genes, Candidate cardiovascular disease genes, FDA approved drug targets, RAS pathway related proteins, Transporters
Intracellular, Secreted (different isoforms)
Cell type enhanced (Astrocytes, Fibroblasts, Oligodendrocyte precursor cells, Endometrial stromal cells, Adipocytes)
Not detected in immune cells
Cell line enhanced (BJ, BJ hTERT+, fHDF/TERT166, hTERT-HME1)
Monomer. Homodimer. Interacts with FGFR1, FGFR2, FGFR3 and FGFR4. Affinity between fibroblast growth factors (FGFs) and their receptors is increased by heparan sulfate glycosaminoglycans that function as coreceptors. Interacts with CSPG4, FGFBP1 and TEC. Found in a complex with FGFBP1, FGF1 and FGF2. Interacts with FGFBP3 (PubMed:18669637). Interacts with integrin ITGAV:ITGB3; the interaction is required for FGF2 signaling (PubMed:28302677). Interacts with SNORC (via the extracellular domain) (By similarity). Interacts with glypican GPC3 (By similarity).
Developmental protein, Growth factor, Heparin-binding, Mitogen
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For Research Use Only. Not For Clinical Use.