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FGF23

This gene encodes a member of the fibroblast growth factor family of proteins, which possess broad mitogenic and cell survival activities and are involved in a variety of biological processes. The product of this gene regulates phosphate homeostasis and transport in the kidney. The full-length, functional protein may be deactivated via cleavage into N-terminal and C-terminal chains. Mutation of this cleavage site causes autosomal dominant hypophosphatemic rickets (ADHR). Mutations in this gene are also associated with hyperphosphatemic familial tumoral calcinosis (HFTC).
FGF23
Protein class

Cancer-related genes, Disease related genes, Human disease related genes, Plasma proteins, Potential drug targets, RAS pathway related proteins, Transporters

Predicted location

Secreted

Single cell type specificity

Group enriched (Hepatic stellate cells, Cone photoreceptor cells, Early spermatids)

Immune cell specificity

Immune cell enhanced (basophil)

Cell line specificity

Cell line enhanced (AF22, HBEC3-KT)

Interaction

Interacts with FGFR1, FGFR2, FGFR3 and FGFR4. Affinity between fibroblast growth factors (FGFs) and their receptors is increased by KL and heparan sulfate glycosaminoglycans that function as coreceptors (By similarity).

Molecular function

Growth factor

More Types Infomation

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