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FGF4

The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities and are involved in a variety of biological processes including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. This gene was identified by its oncogenic transforming activity. This gene and FGF3, another oncogenic growth factor, are located closely on chromosome 11. Co-amplification of both genes was found in various kinds of human tumors. Studies on the mouse homolog suggested a function in bone morphogenesis and limb development through the sonic hedgehog (SHH) signaling pathway.
FGF4
Protein class

Cancer-related genes, RAS pathway related proteins

Predicted location

Secreted

Single cell type specificity

Group enriched (Early spermatids, Spermatocytes, Late spermatids, Cardiomyocytes)

Immune cell specificity

Not detected in immune cells

Cell line specificity

Group enriched (NTERA-2, SuSa)

Interaction

Interacts with FGFR1, FGFR2, FGFR3 and FGFR4. Affinity between fibroblast growth factors (FGFs) and their receptors is increased by heparan sulfate glycosaminoglycans that function as coreceptors.

Molecular function

Developmental protein, Growth factor, Heparin-binding, Mitogen

More Types Infomation

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For Research Use Only. Not For Clinical Use.

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