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FUS
This gene encodes a multifunctional protein component of the heterogeneous nuclear ribonucleoprotein (hnRNP) complex. The hnRNP complex is involved in pre-mRNA splicing and the export of fully processed mRNA to the cytoplasm. This protein belongs to the FET family of RNA-binding proteins which have been implicated in cellular processes that include regulation of gene expression, maintenance of genomic integrity and mRNA/microRNA processing. Alternative splicing results in multiple transcript variants. Defects in this gene result in amyotrophic lateral sclerosis type 6.
Protein class
Cancer-related genes, Disease related genes, Human disease related genes, Plasma proteins
Predicted location
Intracellular
Single cell type specificity
Low cell type specificity
Immune cell specificity
Low immune cell specificity
Cell line specificity
Low cell line specificity
Interaction
Self-oligomerizes (via N-terminal region) (PubMed:25453086). Oligomerization is essential for chromatin binding (PubMed:25453086). Component of nuclear riboprotein complexes. Interacts with ILF3, TDRD3 and SF1 (PubMed:9660765). Interacts through its C-terminus with SFRS13A (PubMed:9774382). Interacts with OTUB1 and SARNP. Interacts with LRSAM1 (PubMed:27615052). Interacts with SAFB1 in a DNA-dependent manner; this interaction tethers FUS to chromatin (PubMed:27731383). Interacts with MATR3 (PubMed:27731383). Interacts with SNRNP70 and POLR2A; these interactions couple RNA transcription and splicing (PubMed:26124092). Interacts (through its RNA-binding domain) with RALY (through its RNA-binding domain); both are components of the same RNPs (PubMed:30354839).
Molecular function
DNA-binding, RNA-binding
More Types Infomation
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- Class: Class I
- Antigen: FUS/TLS
- Antigen Species: Gallus gallus
- Peptide: IDWFEGKE
- Conjugate: APC
-
- Class: Class I
- Antigen: FUS/TLS
- Antigen Species: Gallus gallus
- Peptide: IDWFEGKE
- Conjugate: PE
-
- Class: Class I
- Antigen: FUS/TLS
- Antigen Species: Gallus gallus
- Peptide: IDWFDGKD
- Conjugate: PE
-
- Class: Class I
- Antigen: FUS/TLS
- Antigen Species: Gallus gallus
- Peptide: IDWFDGKE
- Conjugate: PE
-
- Class: Class I
- Antigen: FUS/TLS
- Antigen Species: Gallus gallus
- Peptide: IDWFEGKE
- Conjugate: BV421
-
- Class: Class I
- Antigen: FUS/TLS
- Antigen Species: Gallus gallus
- Peptide: IDWFDGKD
- Conjugate: BV421
-
- Class: Class I
- Antigen: FUS/TLS
- Antigen Species: Gallus gallus
- Peptide: IDWFDGKE
- Conjugate: BV421
-
- Class: Class I
- Antigen: FUS/TLS
- Antigen Species: Gallus gallus
- Peptide: IDWFDGKD
- Conjugate: APC
-
- Class: Class I
- Antigen: FUS/TLS
- Antigen Species: Gallus gallus
- Peptide: IDWFDGKE
- Conjugate: APC
- Rabbit Anti-FUS Recombinant Antibody (clone CBACN-233) (MRO-0614-CN)
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- Species Reactivity: Human, Mouse, Rat
- Type: Rabbit IgG
- Application: WB, IF, IHC, FC
- Mouse Anti-FUS Recombinant Antibody (clone 44H2) (MOB-4041z)
-
- Derivation: Mouse
- Species Reactivity: Human
- Type: Mouse IgG1
- Application: WB, ELISA, IF, IHC, IP
-
- Derivation: Phage display library
- Species Reactivity: Human
- Type: Rabbit IgG
- Application: WB, IHC, ICC, FC
- Rabbit Anti-FUS Recombinant Antibody (VS3-CJ906) (VS3-CJ906)
-
- Species Reactivity: Human, Mouse, Rat
- Type: Rabbit IgG
- Application: WB, ICC, IF, IHC, FC
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For Research Use Only. Not For Clinical Use.