Enzymes, Plasma proteins
Intracellular, Membrane (different isoforms)
Low cell type specificity
Low immune cell specificity
Low cell line specificity
Homodimer and oligomer (PubMed:12642610, 24324649). Component of a TAU mRNP complex, at least composed of IGF2BP1, ELAVL4 and G3BP1 (By similarity). Binds to the SH3 domain of Ras GTPase-activating protein (RASA1) in proliferating cells (By similarity). No interaction in quiescent cells (By similarity). Interacts (via NTF2-like domain) with USP10 (PubMed:11439350, 23279204). Interacts with RPTOR and SPAG5; this complex is increased by oxidative stress (PubMed:23953116). Interacts with ATXN2L (PubMed:23209657). Interacts with STYXL1 (PubMed:20180778). Interacts with CGAS (via N-terminus); this interaction promotes the DNA-binding and activation of CGAS (PubMed:30510222). Interacts (via C-terminus) with DDX58 (PubMed:30804210). Interacts (via NTF2-like domain) with CAPRIN1 (PubMed:17210633). Interacts with PABPC1 (PubMed:23279204). (Microbial infection) Interacts with Semliki forest virus non-structural protein 3 (via C-terminus); this interaction inhibits the formation of host stress granules on viral mRNAs and the nsp3-G3BP1 complexes bind viral RNAs and probably orchestrate the assembly of viral replication complexes. (Microbial infection) Interacts with Chikungunya virus non-structural protein 3 (via C-terminus); this interaction inhibits the formation of host stress granules on viral mRNAs and the nsp3-G3BP1 complexes bind viral RNAs and probably orchestrate the assembly of viral replication complexes. (Microbial infection) Interacts with Sindbis virus non-structural protein 3 (via C-terminus); this interaction inhibits the formation of host stress granules on viral mRNAs and the nsp3-G3BP1 complexes bind viral RNAs and probably orchestrate the assembly of viral replication complexes.
DNA-binding, Endonuclease, Helicase, Hydrolase, Nuclease, RNA-binding
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For Research Use Only. Not For Clinical Use.