Disease related genes, Human disease related genes, RAS pathway related proteins
Intracellular
Cell type enhanced (Oligodendrocytes, Oligodendrocyte precursor cells, Microglial cells, Excitatory neurons)
Immune cell enhanced (NK-cell)
Cell line enhanced (REH)
Identified in a complex containing FRS2, GRB2, GAB1, PIK3R1 and SOS1 (By similarity). Forms a tripartite complex containing GAB1, METTL13 and SPRY2 (PubMed:29408807). Within the complex interacts with METTL13 (PubMed:29408807). Interacts with GRB2 and with other SH2-containing proteins (PubMed:15010462). Interacts with phosphorylated LAT2 (PubMed:12486104). Interacts with PTPRJ (PubMed:12475979). Interacts (phosphorylated) with PTPN11 (PubMed:15010462). Interacts with HCK (PubMed:15010462).
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For Research Use Only. Not For Clinical Use.