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GAB2
This gene is a member of the GRB2-associated binding protein (GAB) gene family. These proteins contain pleckstrin homology (PH) domain, and bind SHP2 tyrosine phosphatase and GRB2 adapter protein. They act as adapters for transmitting various signals in response to stimuli through cytokine and growth factor receptors, and T- and B-cell antigen receptors. The protein encoded by this gene is the principal activator of phosphatidylinositol-3 kinase in response to activation of the high affinity IgE receptor. Two alternatively spliced transcripts encoding different isoforms have been described for this gene.
Protein class
RAS pathway related proteins
Predicted location
Intracellular
Single cell type specificity
Cell type enhanced (Oligodendrocytes, Microglial cells, Inhibitory neurons, Oligodendrocyte precursor cells)
Immune cell specificity
Immune cell enhanced (neutrophil, basophil)
Cell line specificity
Cell line enhanced (SH-SY5Y)
Interaction
Interacts with SHC1; may mediate interaction with receptors (By similarity). Interacts with SYK (By similarity). Interacts with PI-3 kinase. Interacts with GRB2 (via SH3 2 domain). Interacts (phosphorylated) with PTPN11. Interacts with TNFRSF11A (via cytoplasmic domain). Interacts (phosphorylated) with 14-3-3 family proteins SFN, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ and YWHAZ; prevents interaction with GRB2 and attenuates GAB2 signaling. Interacts with HCK.
More Types Infomation
Related Signaling Pathways
FcεR1 Signaling Pathway
- Recombinant Anti-Human GAB2 Antibody scFv Fragment (MOB-2612z-S(P))
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- Derivation: Mouse
- Species Reactivity: Human
- Type: scFv
- Application: WB, FC, FuncS
- Recombinant Anti-Human GAB2 Antibody Fab Fragment (MOB-2612z-F(E))
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- Derivation: Mouse
- Species Reactivity: Human
- Type: Fab
- Application: WB, IF, FuncS
- Mouse Anti-GAB2 Recombinant Antibody (MOB-2612z) (MOB-2612z)
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- Species Reactivity: Human, Mouse, Rat
- Type: Mouse IgG1, κ
- Application: ELISA, WB, IP, IF, IHC, FC
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- Species Reactivity: Human
- Type: Mouse IgG2a
- Application: IHC, ICC, FC
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For Research Use Only. Not For Clinical Use.