Loading...
GADD45A
This gene is a member of a group of genes whose transcript levels are increased following stressful growth arrest conditions and treatment with DNA-damaging agents. The protein encoded by this gene responds to environmental stresses by mediating activation of the p38/JNK pathway via MTK1/MEKK4 kinase. The DNA damage-induced transcription of this gene is mediated by both p53-dependent and -independent mechanisms. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.[provided by RefSeq, Dec 2010]
Protein class
Cancer-related genes
Predicted location
Intracellular
Single cell type specificity
Cell type enhanced (Basal prostatic cells, Urothelial cells, Glandular and luminal cells, Basal keratinocytes)
Immune cell specificity
Immune cell enhanced (eosinophil)
Cell line specificity
Cell line enhanced (HHSteC, hTERT-HME1)
Interaction
Interacts with MAPK14 (By similarity). Predominantly monomeric but also forms dimers and other oligomers as concentration increases. Interacts with GADD45GIP1. Interacts weakly with PCNA. Interacts with AURKA, likely to compete with dimerization.
More Types Infomation
Related Diseases
Breast Cancer
Endometrial Cancer
Gastric Cancer
Prostate Cancer
Throid Cancer
Related Signaling Pathways
p53 Signaling Pathway
- Recombinant Mouse Anti-Human GADD45A Antibody (MOB-2431MZ)
-
- Species Reactivity: Human
- Type: Mouse antibody
- Application: WB
-
- Species Reactivity: Human
- Type: Mouse IgG
- Application: WB
-
- Derivation: Mouse
- Species Reactivity: Human
- Type: Mouse IgG1
- Application: WB
Our customer service representatives are available 24 hours a day, from Monday to Sunday. Contact Us
Can't find the products you're looking for? Try to filter in the left sidebar.Filter By Tag
For Research Use Only. Not For Clinical Use.