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GAPDH
This gene encodes a member of the glyceraldehyde-3-phosphate dehydrogenase protein family. The encoded protein has been identified as a moonlighting protein based on its ability to perform mechanistically distinct functions. The product of this gene catalyzes an important energy-yielding step in carbohydrate metabolism, the reversible oxidative phosphorylation of glyceraldehyde-3-phosphate in the presence of inorganic phosphate and nicotinamide adenine dinucleotide (NAD). The encoded protein has additionally been identified to have uracil DNA glycosylase activity in the nucleus. Also, this protein contains a peptide that has antimicrobial activity against E. coli, P. aeruginosa, and C. albicans. Studies of a similar protein in mouse have assigned a variety of additional functions including nitrosylation of nuclear proteins, the regulation of mRNA stability, and acting as a transferrin receptor on the cell surface of macrophage. Many pseudogenes similar to this locus are present in the human genome. Alternative splicing results in multiple transcript variants.
Protein class
Enzymes, FDA approved drug targets, Metabolic proteins, Plasma proteins
Predicted location
Intracellular
Single cell type specificity
Cell type enhanced (Extravillous trophoblasts)
Immune cell specificity
Low immune cell specificity
Cell line specificity
Low cell line specificity
Interaction
Homotetramer (PubMed:16239728, 16510976). Interacts with TPPP; the interaction is direct (By similarity). Interacts (when S-nitrosylated) with SIAH1; leading to nuclear translocation (By similarity). Interacts with RILPL1/GOSPEL, leading to prevent the interaction between GAPDH and SIAH1 and prevent nuclear translocation (By similarity). Interacts with CHP1; the interaction increases the binding of CHP1 with microtubules (By similarity). Associates with microtubules (By similarity). Interacts with EIF1AD, USP25, PRKCI and WARS1 (PubMed:11724794, 16501887, 15628863, 20644585). Interacts with phosphorylated RPL13A; inhibited by oxidatively-modified low-densitity lipoprotein (LDL(ox)) (PubMed:22771119). Component of the GAIT complex (PubMed:15479637). Interacts with FKBP6; leading to inhibit GAPDH catalytic activity (PubMed:19001379). Interacts with TRAF2, promoting TRAF2 ubiquitination (PubMed:23332158). Interacts with TRAF3, promoting TRAF3 ubiquitination (PubMed:27387501).
Molecular function
Oxidoreductase, Transferase
More Types Infomation
- Recombinant Human Anti-human GAPDH Antibody Fab Fragment (MHH-386-F(E))
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- Derivation: Human
- Species Reactivity: Human
- Type: Fab
- Application: ELISA, WB, IP, FuncS
- Recombinant Human Anti-human GAPDH Antibody scFv Fragment (MHH-386-S(P))
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- Derivation: Human
- Species Reactivity: Human
- Type: scFv
- Application: WB, FC, FuncS
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- Derivation: Human
- Species Reactivity: Human
- Type: IgG
- Application: ELISA, WB, FC, FuncS
- Recombinant Anti-human GAPDH Antibody Fab Fragment (MOB-386-F(E))
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- Derivation: Mouse
- Species Reactivity: Human
- Type: Fab
- Application: IP, RIA, FuncS
- Recombinant Anti-human GAPDH Antibody (MOB-386)
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- Derivation: Mouse
- Species Reactivity: Human
- Type: IgG
- Application: WB, IHC, FuncS
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- Species Reactivity: Human
- Type: Mouse antibody
- Application: ELISA
- Human Anti-GAPDH Antibody (clone lesion), mRNA (FAMAB-0117YC-mRNA)
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- Species Reactivity: Human
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- Species Reactivity: Human, Mouse, Rat, Monkey, Chicken, Fish
- Type: Rabbit IgG
- Application: WB
- Mouse Anti-GAPDH Recombinant Antibody (clone 5-E10) (MRO-0632-CN)
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- Species Reactivity: Human, Mouse, Rat, Zebrafish, Rabbit
- Type: Mouse IgM
- Application: WB, IF
- Rabbit Anti-GAPDH Recombinant Antibody (clone CBACN-235) (MRO-0631-CN)
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- Species Reactivity: Human, Mouse, Rat, Monkey, Chicken, Zebrafish
- Type: Rabbit IgG
- Application: WB, IF, IHC, IP, FC
- Rabbit Anti-GAPDH Polyclonal Antibody (MRO-0208YJ)
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- Species Reactivity: Human, Monkey
- Type: Rabbit IgG
- Application: WB, IF, ICC, ELISA
- Mouse Anti-GAPDH Polyclonal Antibody (MRO-0202YJ)
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- Species Reactivity: Human, Mouse, Rat, Pig, Zebrafish, Bovine, Sheep, Rabbit, Goat, Guinea pig, Dog, Monkey, Hamster, Chicken, Plants, Rice, Fish
- Type: Mouse IgG
- Application: WB, ELISA
- Rabbit Anti-GAPDH Recombinant Antibody (clone AFY0072) (MOR-0101-FY)
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- Species Reactivity: Human
- Type: Rabbit IgG
- Application: IF, IHC-P, WB
- Rabbit Anti-GAPDH Polyclonal Antibody (MRO-1885-CN) (MRO-1885-CN)
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- Species Reactivity: Human, Mouse, Rat
- Type: Rabbit IgG
- Application: WB, IF, IHC, FC
- Rabbit Anti-GAPDH Polyclonal Antibody (MRO-1884-CN) (MRO-1884-CN)
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- Species Reactivity: Human, Mouse, Rat, Zebrafish, Rabbit
- Type: Rabbit IgG
- Application: WB, IF, IHC, FC
- Rabbit Anti-GAPDH Polyclonal Antibody (MRO-1883-CN) (MRO-1883-CN)
-
- Species Reactivity: Human, Mouse, Rat
- Type: Rabbit IgG
- Application: WB, IF, IHC, FC
- Human Anti-GAPDH Recombinant Antibody (clone lesion); Fab Fragment (FAMAB-0117-YC-F(E))
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- Species Reactivity: Human
- Type: Human Fab
- Application: ELISA, WB
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- Derivation: Phage display library
- Species Reactivity: Human
- Type: Rabbit IgG
- Application: WB, ICC, IP, FC
- Mouse Anti-GAPDH Recombinant Antibody (clone 1-G2) (MRO-0630-CN)
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- Species Reactivity: Human, Mouse, Rat, Zebrafish
- Type: Mouse IgG2b
- Application: WB, IF
- Human Anti-GAPDH Recombinant Antibody (clone lesion) (FAMAB-0117YC)
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- Species Reactivity: Human
- Type: Human IgG
- Application: ELISA, WB
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For Research Use Only. Not For Clinical Use.