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GGT1

The enzyme encoded by this gene is a type I gamma-glutamyltransferase that catalyzes the transfer of the glutamyl moiety of glutathione to a variety of amino acids and dipeptide acceptors. The enzyme is composed of a heavy chain and a light chain, which are derived from a single precursor protein. It is expressed in tissues involved in absorption and secretion and may contribute to the etiology of diabetes and other metabolic disorders. Multiple alternatively spliced variants have been identified. There are a number of related genes present on chromosomes 20 and 22, and putative pseudogenes for this gene on chromosomes 2, 13, and 22.
Protein class

Candidate cardiovascular disease genes, CD markers, Disease related genes, Enzymes, Metabolic proteins, Plasma proteins, Potential drug targets

Predicted location

Intracellular, Membrane (different isoforms)

Single cell type specificity

Cell type enhanced (Proximal enterocytes, Ductal cells, Alveolar cells type 1, Proximal tubular cells, Distal enterocytes, Cholangiocytes, Hepatocytes)

Immune cell specificity

Low immune cell specificity

Cell line specificity

Cell line enhanced (HDLM-2, Karpas-707, OE19, RPMI-8226, RPTEC TERT1)

Interaction

Heterodimer composed of the light and heavy chains. The active site is located in the light chain.

Molecular function

Acyltransferase, Hydrolase, Protease, Transferase

More Types Infomation

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For Research Use Only. Not For Clinical Use.

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