Disease related genes
Intracellular
Cell type enhanced (Early spermatids, Late spermatids, Spermatogonia, Extravillous trophoblasts, Erythroid cells, Spermatocytes)
Not detected in immune cells
Low cell line specificity
Component of the GINS complex which is a heterotetramer of GINS1, GINS2, GINS3 and GINS4 (PubMed:17545466, PubMed:17557111, PubMed:17652513, PubMed:28414293). Forms a stable subcomplex with GINS4. GINS complex interacts with DNA primase in vitro (PubMed:17545466, PubMed:17557111, PubMed:17652513, PubMed:28414293). Component of the CMG helicase complex, composed of the MCM2-7 complex, the GINS complex and CDC45 (By similarity).
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For Research Use Only. Not For Clinical Use.