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GLRA1
Enables extracellularly glycine-gated chloride channel activity; glycine binding activity; and identical protein binding activity. Involved in chloride transport and glycinergic synaptic transmission. Located in endoplasmic reticulum and external side of plasma membrane. Is active in calyx of Held and glycinergic synapse. Is integral component of postsynaptic specialization membrane and integral component of presynaptic membrane. Human ortholog(s) of this gene implicated in hyperekplexia 1. Orthologous to human GLRA1 (glycine receptor alpha 1).
Protein class
Disease related genes, FDA approved drug targets, Human disease related genes, Transporters
Predicted location
Membrane
Single cell type specificity
Cell type enhanced (Bipolar cells, Inhibitory neurons, Excitatory neurons, Horizontal cells, Oligodendrocyte precursor cells)
Immune cell specificity
Not detected in immune cells
Cell line specificity
Not detected
Interaction
Homopentamer (in vitro) (PubMed:22715885, PubMed:22973015, PubMed:23994010, PubMed:25730860). Interacts with GLRB to form heteropentameric channels; this is probably the predominant form in vivo (PubMed:22715885, PubMed:22973015, PubMed:25445488). Heteropentamer composed of two GLRA1 and three GLRB (PubMed:22715885). Heteropentamer composed of three GLRA1 and two GLRB (PubMed:22973015). Both homopentamers and heteropentamers form functional ion channels, but their characteristics are subtly different (PubMed:14551753, PubMed:22715885, PubMed:22973015, PubMed:25445488, PubMed:23994010, PubMed:25730860).
Molecular function
Chloride channel, Ion channel, Ligand-gated ion channel, Receptor
More Types Infomation
- Recombinant Mouse Anti-Human GLRA1 Antibody (MOB-0584MZ)
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- Species Reactivity: Human
- Type: Mouse antibody
- Application: WB
- Guinea pig Anti-GLRA1 Recombinant Antibody (VS-0223-WK35) (VS-0223-WK35)
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- Derivation: Guinea pig
- Species Reactivity: Human, Rat, Mouse, Pig, Zebrafish
- Type: Guinea pig IgG
- Application: WB, IHC
- Rabbit Anti-GLRA1 Recombinant Antibody (VS-0223-WK34) (VS-0223-WK34)
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- Derivation: Rabbit
- Species Reactivity: Human, Rat, Mouse, Pig, Zebrafish
- Type: Rabbit IgG
- Application: WB, ICC, IHC, IHC-P
- Rabbit Anti-GLRA1 Recombinant Antibody (VS-0223-WK36) (VS-0223-WK36)
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- Derivation: Rabbit
- Species Reactivity: Human, Rat, Mouse, Pig, Zebrafish
- Type: Rabbit IgG
- Application: ICC, IHC
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For Research Use Only. Not For Clinical Use.