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GPR132

This gene encodes a member of the guanine nucleotide-binding protein (G protein)-coupled receptor (GPCR) superfamily. The receptors are seven-pass transmembrane proteins that respond to extracellular cues and activate intracellular signal transduction pathways. This protein was reported to be a receptor for lysophosphatidylcholine action, but PubMedID: 15653487 retracts this finding and instead suggests this protein to be an effector of lysophosphatidylcholine action. This protein may have proton-sensing activity and may be a receptor for oxidized free fatty acids. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]
Protein class

G-protein coupled receptors

Predicted location

Intracellular, Membrane (different isoforms)

Single cell type specificity

Cell type enhanced (Langerhans cells, Macrophages, B-cells, T-cells, monocytes, NK-cells)

Immune cell specificity

Low immune cell specificity

Cell line specificity

Group enriched (HDLM-2, Karpas-707, THP-1)

Molecular function

G-protein coupled receptor, Receptor, Transducer

More Types Infomation

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For Research Use Only. Not For Clinical Use.

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