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GTF2H1

General transcription factor IIH subunit 1 is a protein that in humans is encoded by the GTF2H1 gene.
Protein class

Cancer-related genes

Predicted location

Intracellular

Single cell type specificity

Low cell type specificity

Immune cell specificity

Low immune cell specificity

Cell line specificity

Low cell line specificity

Interaction

Component of the 7-subunit TFIIH core complex composed of XPB/ERCC3, XPD/ERCC2, GTF2H1, GTF2H2, GTF2H3, GTF2H4 and GTF2H5, which is active in NER. The core complex associates with the 3-subunit CDK-activating kinase (CAK) module composed of CCNH/cyclin H, CDK7 and MNAT1 to form the 10-subunit holoenzyme (holo-TFIIH) active in transcription. Interacts with PUF60. (Microbial infection) interacts with Rift valley fever virus NSs (via OmegaXaV motif).

More Types Infomation

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For Research Use Only. Not For Clinical Use.

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