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HAO1

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Hydroxyacid oxidase 1, also known asGlycolate oxidase, HAO1 and GOX1, is a member of the FMN-dependentalpha-hydroxy acid dehydrogenase family. HAO1 / GOX1 has 2-hydroxyacid oxidase activity. It is mostactive on the 2-carbon substrate glycolate, but is also active on 2-hydroxyfatty acids, with high activity towards 2-hydroxy palmitate and 2-hydroxyoctanoate. HAO1 / GOX1is a liver-specific peroxisomal enzyme that oxidizes glycolate to glyoxylatewith concomitant production of H2O2. In Hao1 messenger RNA (mRNA), an iron-responsiveelement (IRE) homologous to the sequence recognized by iron regulatory proteins(IRP), key regulators of iron homeostasis, is present. Mammalian HAO1 / GOX1 is a peroxisomal protein andthat the C-terminal sequence SKI acts as the targeting signal. Down-regulationof HAO1 / GOX1 expression during oxidativestress may provide a mechanism to prevent excessive H2O2 formation in liverperoxisomes and may represent the prototype of a poorly recognized butpotentially relevant response to oxidative injury involving down-regulation ofROS-producing enzymes.

Derivation:
Mouse
Species Reactivity:
Human
Type:
IgG
Application:
ELISA, IP, FuncS
Derivation:
Mouse
Species Reactivity:
Human
Type:
Fab
Application:
RIA, WB, FuncS
Derivation:
Mouse
Species Reactivity:
Human
Type:
scFv
Application:
ELISA, WB, IP, FuncS
Species Reactivity:
Human
Type:
IgG
Application:
ELISA
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