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HCN4
HCN4 (Hyperpolarization Activated Cyclic Nucleotide Gated Potassium Channel 4) is a Protein Coding gene. This gene encodes a member of the hyperpolarization-activated cyclic nucleotide-gated potassium channels. The encoded protein shows slow kinetics of activation and inactivation, and is necessary for the cardiac pacemaking process. Diseases associated with HCN4 include Sick Sinus Syndrome 2 and Brugada Syndrome 8.
Protein class
Disease related genes, Human disease related genes, Potential drug targets, Transporters, Voltage-gated ion channels
Predicted location
Membrane
Single cell type specificity
Group enriched (Late spermatids, Early spermatids)
Immune cell specificity
Not detected in immune cells
Cell line specificity
Cell line enhanced (AF22, CACO-2, HDLM-2, NTERA-2, SuSa, U-2 OS)
Interaction
Homotetramer. The potassium channel is composed of a homo- or heterotetrameric complex of pore-forming subunits.
Molecular function
Ion channel, Ligand-gated ion channel, Potassium channel, Sodium channel, Voltage-gated channel
More Types Infomation
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- Species Reactivity: Human
- Type: Mouse antibody
- Application: ELISA
- Rabbit Anti-HCN4 Recombinant Antibody (clone rN114/10.1) (VS-0422-LC119)
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- Species Reactivity: Rat, Human
- Type: Rabbit IgG
- Application: IP, WB, IF, IHC
- Human Anti-HCN4 Recombinant Antibody (clone hN114/10.1) (VS-0422-LC118)
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- Species Reactivity: Rat, Human
- Type: Human IgG1
- Application: IP, WB, IF, IHC
- Rat Anti-HCN4 Recombinant Antibody (clone rtN114/10.1) (VS-0422-LC117)
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- Species Reactivity: Rat, Human
- Type: Rat IgG2b
- Application: IP, WB, IF, IHC
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For Research Use Only. Not For Clinical Use.