Hepatoma-derived growth factor (HDCF) is a heparin-binding growth factor originally isolated from the serum-free supernatant of human liver cancer HuH-7 cell line as a growth factor in cancer. The expression is up-regulated. And closely related to the occurrence and development of a variety of cancers. Studies have shown that HDGF expression is up-regulated in patients with early cervical cancer, and down-regulation of HDCF levels in patients makes lung cancer metastasis slower. Therefore, related research on HDGF as a cancer treatment target is also popular. HDCF levels have been shown to be prognostic factors for some cancers including gastric cancer, liver cancer, non-small cell lung cancer, esophageal cancer, and pancreatic cancer. Recent studies have shown that HDGF has an activity that promotes mitosis of various types of cells including hepatocellular carcinoma cells, fibroblasts, endothelial cells, vascular smooth muscle cells, and fetal liver cells. In addition, HDGF is involved in other cellular processes such as kidney development, cardiovascular differentiation, angiogenesis, and sensitivity of cancer cells to treatment.
HDCF can promote the proliferation and differentiation of tumor cells, and also enhance the metastatic ability of tumor cells through EMT. In the process of carcinogenesis of spontaneous hepatocellular carcinoma in mice, HDGF expression was significantly increased after carcinogenesis; HDGF expression was increased in tumor tissues such as liver cancer, non-small cell lung cancer, pancreatic cancer and gastric cancer, and its expression was associated with prognosis. The HDCF gene is involved in the differentiation and division of various tissues. The related mechanisms of HDGF and tumors have been reported in large numbers. Firstly, HDGF was found to be associated with microvessel density in tumors, promoting the proliferation of cancer cells such as lung cancer and the formation of tumor new blood vessels. Secondly, HDCF can induce regulatory T cell formation. Down-regulates the body's immune response to tumors; in addition, HDGF was found to affect epithelial-mesenchymal transition (EMT) and related malignant changes in breast cancer to promote breast cancer development; the latest study also found HDCF and patients Specific genotypes are associated and can interact with other molecules. Recent studies have shown that HDGF is closely related to the occurrence and development of tumors.
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