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HEY1
This gene encodes a nuclear protein belonging to the hairy and enhancer of split-related (HESR) family of basic helix-loop-helix (bHLH)-type transcriptional repressors. Expression of this gene is induced by the Notch and c-Jun signal transduction pathways. Two similar and redundant genes in mouse are required for embryonic cardiovascular development, and are also implicated in neurogenesis and somitogenesis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2008]
Protein class
Cancer-related genes, Transcription factors, Transporters
Predicted location
Intracellular
Single cell type specificity
Cell type enhanced (Extravillous trophoblasts, Adipocytes, Skeletal myocytes, Endothelial cells)
Immune cell specificity
Immune cell enriched (neutrophil)
Cell line specificity
Cell line enhanced (HEK93, PC-3, SK-MEL-30, WM-115)
Interaction
Self-associates. Interacts with HES1 and HEYL. Interacts with HDAC1, NCOR1 and SIN3A. Interacts with GATA4 and GATA6. Interacts with CCDC89/BOIP.
Molecular function
Developmental protein, DNA-binding, Repressor
More Types Infomation
Related Diseases
Breast Cancer
-
- Species Reactivity: Human
- Application: WB
- Chicken Anti-HEY1 Polyclonal IgY (BRD-1071MZ)
-
- Species Reactivity: Human, Mouse, Rat
- Type: Chicken antibody
- Application: ELISA, WB
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For Research Use Only. Not For Clinical Use.