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HEYL
This gene encodes a member of the hairy and enhancer of split-related (HESR) family of basic helix-loop-helix (bHLH)-type transcription factors. The sequence of the encoded protein contains a conserved bHLH and orange domain, but its YRPW motif has diverged from other HESR family members. It is thought to be an effector of Notch signaling and a regulator of cell fate decisions. Alternatively spliced transcript variants have been found, but their biological validity has not been determined.
Protein class
Transcription factors
Predicted location
Intracellular
Single cell type specificity
Cell type enhanced (Peritubular cells, Sertoli cells, Skeletal myocytes, Smooth muscle cells, Leydig cells, Late spermatids)
Immune cell specificity
Not detected in immune cells
Cell line specificity
Cell line enhanced (JURKAT, LHCN-M2, RH-30, THP-1, U-266/84)
Interaction
Self-associates. Interacts with GATA4, GATA6, HES1, HEY1 and HEY2. Interacts with HDAC1, NCOR1 and SIN3A.
Molecular function
Developmental protein, DNA-binding, Repressor
More Types Infomation
- Chicken Anti-HEYL (ab2) Polyclonal IgY (BRD-0254MZ)
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- Species Reactivity: Human
- Type: Chicken antibody
- Application: WB
- Chicken Anti-HEYL (ab1) Polyclonal IgY (BRD-0253MZ)
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- Species Reactivity: Human
- Type: Chicken antibody
- Application: WB
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For Research Use Only. Not For Clinical Use.