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HIST1H4A

HIST1H4A

Engineered Antibody

Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling

Protein class

Disease related genes

Predicted location

Intracellular

Single cell type specificity

Not detected

Immune cell specificity

Group enriched (neutrophil, eosinophil)

Cell line specificity

Cell line enhanced (MOLT-4, NB-4, REH)

Interaction

The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA (By similarity). Found in a co-chaperone complex with DNJC9, MCM2 and histone H3.3-H4 dimers (PubMed:33857403). Within the complex, interacts with DNJC9 (via C-terminus); the interaction is direct (PubMed:33857403).

Molecular function

DNA-binding

More Types Infomation

Rabbit Anti-HIST1H4A Recombinant Antibody (clone CBACN-691) (MRO-2408-CN)
- Species Reactivity: Human, Mouse, Rat
- Type: Rabbit IgG
- Application: WB, IHC

Rabbit Anti-HIST1H4A Recombinant Antibody (clone CBACN-682) (MRO-2399-CN)
- Species Reactivity: Human, Mouse, Rat
- Type: Rabbit IgG
- Application: WB, IF, IHC, IP

Rabbit Anti-HIST1H4A Recombinant Antibody (clone JB21-44) (MRO-2398-CN)
- Species Reactivity: Human, Mouse, Rat
- Type: Rabbit IgG
- Application: WB, IF, IHC, FC

Rabbit Anti-HIST1H4A Recombinant Antibody (clone DS1607AB) (MOR-1607)
- Derivation: Phage display library
- Species Reactivity: Human, Mouse, Rat, Monkey
- Type: Rabbit IgG
- Application: WB, IP, IHC-P, IF, ChIP

Rabbit Anti-HIST1H4A Recombinant Antibody (clone CBACN-276) (MRO-0750-CN)
- Species Reactivity: Human, Mouse, Rat
- Type: Rabbit IgG
- Application: WB, IF, IHC

Mouse Anti-HIST1H4A Recombinant Antibody (clone 40H9) (MOB-3478z)
- Derivation: Mouse
- Species Reactivity: Human
- Type: Mouse IgG1
- Application: IHC, IP, WB

Rabbit Anti-HIST1H4A Recombinant Antibody (clone TH110DS) (MOR-4597)
- Species Reactivity: Human
- Type: Rabbit IgG
- Application: WB, IF, ICC, FC

Rabbit Anti-HIST1H4A Recombinant Antibody (clone AFY0018) (MOR-0047-FY)
- Species Reactivity: Human, Mouse
- Type: Rabbit IgG
- Application: IHC-P, IP, WB

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For Research Use Only. Not For Clinical Use.

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