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IFNAR2
The protein encoded by this gene is a type I membrane protein that forms one of the two chains of a receptor for interferons alpha and beta. Binding and activation of the receptor stimulates Janus protein kinases, which in turn phosphorylate several proteins, including STAT1 and STAT2. Multiple transcript variants encoding at least two different isoforms have been found for this gene.
Protein class
Cancer-related genes, Disease related genes, FDA approved drug targets
Predicted location
Intracellular, Membrane, Secreted (different isoforms)
Single cell type specificity
Cell type enhanced (Plasma cells)
Immune cell specificity
Low immune cell specificity
Cell line specificity
Cell line enhanced (Karpas-707, U-266/70, U-266/84)
Interaction
Heterodimer with IFNAR1 (PubMed:8181059, 7665574, 10049744, 24075985, 21854986). Interacts with the transcriptional factors STAT1 and STAT2 (PubMed:9121453, 28165510). Interacts with JAK1 (PubMed:8181059, 7759950). Interacts with USP18; indirectly via STAT2, it negatively regulates the assembly of the ternary interferon-IFNAR1-IFNAR2 complex and therefore type I interferon signaling (PubMed:28165510).
Molecular function
Receptor
More Types Infomation
-
- Derivation: Human
- Species Reactivity: Human
- Type: IgG
- Application: ELISA, WB, IP, FuncS
- Recombinant Anti-human IFNAR2 Antibody scFv Fragment (MOB-536-S(P))
-
- Derivation: Mouse
- Species Reactivity: Human
- Type: scFv
- Application: ELISA, WB, IF, FuncS
- Recombinant Anti-human IFNAR2 Antibody Fab Fragment (MOB-536-F(E))
-
- Derivation: Mouse
- Species Reactivity: Human
- Type: Fab
- Application: RIA, ELISA, FuncS
- Recombinant Anti-human IFNAR2 Antibody (MOB-536)
-
- Derivation: Mouse
- Species Reactivity: Human
- Type: IgG
- Application: WB, Neut, FuncS
-
- Species Reactivity: Human
- Type: Mouse IgG2a
- Application: Neut, FC, IHC, IP
- Recombinant Human Anti-human IFNAR2 Antibody Fab Fragment (MHH-536-F(E))
-
- Derivation: Human
- Species Reactivity: Human
- Type: Fab
- Application: IP, IF, Biosensors, FuncS
-
- Species Reactivity: Human
- Type: Rabbit IgG
- Application: WB
-
- Species Reactivity: Human
- Application: ELISA, WB
- Recombinant Human Anti-human IFNAR2 Antibody scFv Fragment (MHH-536-S(P))
-
- Derivation: Human
- Species Reactivity: Human
- Type: scFv
- Application: ELISA, WB, FuncS
- Chicken Anti-IFNAR2 Polyclonal IgY (BRD-0868MZ)
-
- Species Reactivity: Human
- Type: Chicken antibody
- Application: WB
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For Research Use Only. Not For Clinical Use.