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IGF1
The protein encoded by this gene is similar to insulin in function and structure and is a member of a family of proteins involved in mediating growth and development. The encoded protein is processed from a precursor, bound by a specific receptor, and secreted. Defects in this gene are a cause of insulin-like growth factor I deficiency. Alternative splicing results in multiple transcript variants encoding different isoforms that may undergo similar processing to generate mature protein.
Protein class
Disease related genes, Human disease related genes, Plasma proteins, RAS pathway related proteins
Predicted location
Secreted
Single cell type specificity
Group enriched (Endometrial stromal cells, Leydig cells)
Immune cell specificity
Immune cell enhanced (naive B-cell)
Cell line specificity
Cell line enhanced (ASC diff, HDLM-2, K-562, Karpas-707, U-266/70)
Interaction
Forms a ternary complex with IGFR1 and ITGAV:ITGB3 (PubMed:19578119). Forms a ternary complex with IGFR1 and ITGA6:ITGB4 (PubMed:22351760, PubMed:23696648). Interacts with SH2D3C isoform 2 (PubMed:20881139).
Molecular function
Growth factor
More Types Infomation
Related Signaling Pathways
Insulin Signaling Pathway
Related Diseases
Endocrine Resistance
- PE-H-2Db/Human IGF1 (SHLVEALYL) MHC Tetramer (MHC-CN0897)
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- Class: Class I
- Antigen: IGF1
- Antigen Species: Human
- Peptide: SHLVEALYL
- Conjugate: PE
- APC-H-2Db/Human IGF1 (SHLVEALYL) MHC Tetramer (MHC-CN0898)
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- Class: Class I
- Antigen: IGF1
- Antigen Species: Human
- Peptide: SHLVEALYL
- Conjugate: APC
- FITC-H-2Db/Human IGF1 (SHLVEALYL) MHC Tetramer (MHC-CN0899)
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- Class: Class I
- Antigen: IGF1
- Antigen Species: Human
- Peptide: SHLVEALYL
- Conjugate: FITC
- H-2Db/Human IGF1 (SHLVEALYL) MHC Tetramer (MHC-CN0900)
-
- Class: Class I
- Antigen: IGF1
- Antigen Species: Human
- Peptide: SHLVEALYL
- Conjugate: Unconjugated
-
- Derivation: Phage display library
- Species Reactivity: Human
- Type: Rabbit IgG
- Application: WB
-
- Species Reactivity: Human
- Type: Mouse antibody
- Application: RIA, ELISA
-
- Derivation: Mouse
- Species Reactivity: Human
- Type: Mouse IgG1, κ
- Application: FC, IF, Neut
- Hamster Anti-Igf1 Recombinant Antibody (clone CBL534) (NEUT-1074CQ)
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- Species Reactivity: Mouse
- Type: Hamster IgG
- Application: WB, ELISA, Neut
- Mouse Anti-IGF1 Recombinant Antibody (clone SPM406) (NEUT-1073CQ)
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- Species Reactivity: Human, Mouse, Rat, Rabbit
- Type: Mouse IgG1, κ
- Application: WB, Neut, FC, ICC, IF, IHC-P, IP
- Mouse Anti-IGF1 Recombinant Antibody (clone M23) (NEUT-1072CQ)
-
- Species Reactivity: Mouse, Rat, Rabbit, Human
- Type: Mouse IgG1, κ
- Application: Neut, FC, ICC, IF
- Mouse Anti-IGF1 Recombinant Antibody; Fab Fragment (HPAB-0038-YC-F(E)) (HPAB-0038-YC-F(E))
-
- Species Reactivity: Human
- Type: Mouse Fab
- Application: ELISA
- Human Anti-IGF1 Recombinant Antibody (HPAB-0160-YJ) (HPAB-0160-YJ)
-
- Species Reactivity: Human, Mouse, Rat
- Type: Human IgG1
- Application: ELISA, Neut, FuncS
- Human Anti-IGF1 Recombinant Antibody; scFv Fragment (HPAB-0038LY-S(P)) (HPAB-0038LY-S(P))
-
- Derivation: Human
- Species Reactivity: Human
- Type: Human scfv
- Application: WB
- Human Anti-IGF1 Recombinant Antibody; scFv Fragment (HPAB-0771-CN-S(P)) (HPAB-0771-CN-S(P))
-
- Species Reactivity: Human
- Type: Human scFv
- Application: WB, FC
- Human Anti-IGF1 Recombinant Antibody; scFv Fragment (HPAB-0770-CN-S(P)) (HPAB-0770-CN-S(P))
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- Species Reactivity: Human
- Type: Human scFv
- Application: WB, FC
- Human Anti-IGF1 Recombinant Antibody; Fab Fragment (HPAB-0771-CN-F(E)) (HPAB-0771-CN-F(E))
-
- Species Reactivity: Human
- Type: Human Fab
- Application: WB, FC
- Human Anti-IGF1 Recombinant Antibody; Fab Fragment (HPAB-0770-CN-F(E)) (HPAB-0770-CN-F(E))
-
- Species Reactivity: Human
- Type: Human Fab
- Application: WB, FC
- Anti-Human IGF1 Recombinant Antibody (BI 836845) (TAB-385CL)
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- Derivation: Human
- Species Reactivity: Human
- Type: Antibody
- Application: WB, FuncS
-
- Scaffold Name: Z-domain of protein A
- Target: Insulin
- Species Reactivity: Human
- Derivation: Phage display
- Human Anti-IGF1 Recombinant Antibody (HPAB-0039-YC) (HPAB-0039-YC)
-
- Species Reactivity: Human, Mouse, Rat
- Type: Human IgG1
- Application: ELISA, Stim, Neut
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For Research Use Only. Not For Clinical Use.