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IGF2
This gene encodes a member of the insulin family of polypeptide growth factors, which are involved in development and growth. It is an imprinted gene, expressed only from the paternal allele, and epigenetic changes at this locus are associated with Wilms tumour, Beckwith-Wiedemann syndrome, rhabdomyosarcoma, and Silver-Russell syndrome. A read-through INS-IGF2 gene exists, whose 5' region overlaps the INS gene and the 3' region overlaps this gene. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2010]
Protein class
Cancer-related genes, Disease related genes, Human disease related genes, Plasma proteins, RAS pathway related proteins
Predicted location
Membrane, Secreted (different isoforms)
Single cell type specificity
Cell type enhanced (Extravillous trophoblasts, Leydig cells, Syncytiotrophoblasts, Cytotrophoblasts, Peritubular cells)
Immune cell specificity
Not detected in immune cells
Cell line specificity
Cell line enhanced (CACO-2, Hep G2, LHCN-M2, RH-30, SH-SY5Y)
Interaction
Interacts with MYORG; this interaction is required for IGF2 secretion (By similarity). Interacts with integrins ITGAV:ITGB3 and ITGA6:ITGB4; integrin-binding is required for IGF2 signaling (PubMed:28873464).
Molecular function
Growth factor, Hormone, Mitogen
More Types Infomation
Related Diseases
Endocrine Resistance
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- Species Reactivity: Human
- Type: Human scFv
- Application: WB, ELISA, FuncS
-
- Species Reactivity: Human
- Type: Human Fab
- Application: WB, ELISA, FuncS
- Rabbit Anti-IGF2 Recombinant Antibody (clone CBACN-300) (MRO-0818-CN)
-
- Species Reactivity: Human
- Type: Rabbit IgG
- Application: WB, IF, IHC
-
- Species Reactivity: Human
- Type: Mouse antibody
- Application: WB
-
- Derivation: Phage display library
- Species Reactivity: Human
- Type: Rabbit IgG
- Application: ELISA
- Human Anti-IGF2 Antibody (clone DX-2647), mRNA (PABL-231-mRNA)
-
- Species Reactivity: Human
- Rabbit Anti-IGF2 Recombinant Antibody (clone CBI236) (MOB-251YJL)
-
- Species Reactivity: Mouse
- Type: Rabbit IgG
- Application: ELISA
- Mouse Anti-IGF2 Recombinant Antibody (clone CBL493) (NEUT-1083CQ)
-
- Species Reactivity: Human
- Type: Mouse IgG1
- Application: Neut
-
- Species Reactivity: Human
- Type: Human IgG
- Application: WB, ELISA, FuncS
-
- Species Reactivity: Human
- Type: Rabbit IgG
- Application: ELISA
- Human Anti-IGF2 Recombinant Antibody (clone m616) (HPAB-1735-FY)
-
- Species Reactivity: Human
- Type: Human IgG
- Application: ELISA
-
- Species Reactivity: Human
- Type: Mouse IgG2b
- Application: IHC-P
- Mouse Anti-IGF2 Recombinant Antibody (clone 8H1) (VS3-QX582)
-
- Derivation: Mouse
- Species Reactivity: Human
- Type: Mouse IgG1
- Application: WB, IHC, ICC, FC, ELISA
- Human Anti-IGF2 Recombinant Antibody; scFv Fragment (HPAB-0037LY-S(P)) (HPAB-0037LY-S(P))
-
- Derivation: Human
- Species Reactivity: Human
- Type: Human scfv
- Application: WB
- Human Anti-IGF2 Recombinant Antibody (clone m610) (HPAB-1734-FY)
-
- Species Reactivity: Human
- Type: Human IgG
- Application: Inhib, WB, ELISA
- Human Anti-IGF2 Recombinant Antibody (clone M606) (HPAB-1733-FY)
-
- Species Reactivity: Human
- Type: Human IgG
- Application: Inhib, WB, ELISA
- Human Anti-IGF2 Recombinant Antibody (clone m610.27) (HPAB-0613-WJ)
-
- Derivation: Humanized
- Species Reactivity: Human
- Type: Humanized IgG1
- Application: ELISA, Inhib
- Human Anti-IGF2 Recombinant Antibody (clone m610.27); Fab Fragment (HPAB-0613-WJ-F(E))
-
- Derivation: Humanized
- Species Reactivity: Human
- Type: Humanized Fab
- Application: ELISA, WB
- Human Anti-IGF2 Recombinant Antibody; Fab Fragment (HPAB-0037LY-F(E)) (HPAB-0037LY-F(E))
-
- Derivation: Human
- Species Reactivity: Human
- Type: Human Fab
- Application: WB
- Human Anti-IGF2 Recombinant Antibody (clone m616); scFv Fragment (HPAB-1735-FY-F(E))
-
- Species Reactivity: Human
- Type: Human scFv
- Application: Inhib, WB, ELISA
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For Research Use Only. Not For Clinical Use.