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IGF2BP3

The protein encoded by this gene is primarily found in the nucleolus, where it can bind to the 5' UTR of the insulin-like growth factor II leader 3 mRNA and may repress translation of insulin-like growth factor II during late development. The encoded protein contains several KH domains, which are important in RNA binding and are known to be involved in RNA synthesis and metabolism. A pseudogene exists on chromosome 7, and there are putative pseudogenes on other chromosomes. [provided by RefSeq, Jul 2008]
Predicted location

Intracellular

Single cell type specificity

Group enriched (Extravillous trophoblasts, Cytotrophoblasts, Syncytiotrophoblasts, Early spermatids, Hofbauer cells, Late spermatids)

Immune cell specificity

Not detected in immune cells

Cell line specificity

Cell line enhanced (HUVEC TERT2)

Interaction

Can form homooligomers and heterooligomers with IGF2BP1 and IGF2BP3 in an RNA-dependent manner (PubMed:23640942). Interacts with IGF2BP1 (PubMed:17289661). Interacts with ELAVL1, DHX9, HNRNPU, MATR3 and PABPC1 (PubMed:23640942, PubMed:29476152).

Molecular function

RNA-binding

More Types Infomation

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