Cancer-related genes, Plasma proteins
Intracellular, Secreted (different isoforms)
Cell type enhanced (Extravillous trophoblasts, Urothelial cells, Basal respiratory cells, Fibroblasts, Basal keratinocytes)
Immune cell enriched (plasmacytoid DC)
Cell line enhanced (fHDF/TERT166, U-2197, U-87 MG)
Interacts with XLKD1 (By similarity). Binds IGF2 more than IGF1. Forms a ternary complex of about 140 to 150 kDa with IGF1 or IGF2 and a 85 kDa glycoprotein (ALS). Interacts with humanin; humanin competes with importin KPNB1 for binding to IGFBP3, blocking IGFBP3 nuclear import and IGFBP3-mediated apoptosis (PubMed:14561895, PubMed:19623253, PubMed:26216267). Interacts with TMEM219.
Growth factor binding
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For Research Use Only. Not For Clinical Use.