Disease related genes, Human disease related genes
Secreted
Not detected
Not detected in immune cells
Not detected
Homodimer; disulfide-linked (PubMed:19838198, PubMed:32187518). Heterodimer with IL17A (IL17A-IL17F) (PubMed:17355969). Forms complexes with IL17RA and IL17RC receptors with 2:1 binding stoichiometry: two receptor chains for one interleukin molecule. IL17F homodimer forms predominantly complexes with IL17RC homodimer, whereas IL17A-IL17F favors complexes with IL17RA-IL17RC (PubMed:32187518, PubMed:28827714, PubMed:17911633, PubMed:18684971). IL17RA and IL17RC chains cannot distinguish between IL17A and IL17F molecules, potentially enabling the formation of topologically distinct complexes (PubMed:28827714).
Cytokine
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For Research Use Only. Not For Clinical Use.