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IL18RAP
IL18RAP is an accessory subunit of the heterodimeric receptor for interleukin 18 (IL18), a proinflammatory cytokine involved in inducing cell-mediated immunity. This protein enhances the IL18-binding activity of the IL18 receptor and plays a role in signaling by IL18. Mutations in this gene are associated with Crohn's disease and inflammatory bowel disease, and susceptibility to celiac disease and leprosy.
Protein class
CD markers, Enzymes
Predicted location
Intracellular, Membrane (different isoforms)
Single cell type specificity
Group enriched (NK-cells, dendritic cells, T-cells)
Immune cell specificity
Immune cell enhanced (NK-cell)
Cell line specificity
Cell line enriched (U-937)
Interaction
Forms a ternary complex with IL18 and IL18R1 (PubMed:14528293, PubMed:25500532). Within this complex, IL18R1 is involved in ligand-binding and IL18RAP in signaling leading to NF-kappa-B and JNK activation (Probable).
Molecular function
Hydrolase, Receptor
More Types Infomation
-
- Derivation: Mouse
- Species Reactivity: Human
- Type: Mouse IgG1
- Application: WB, IHC, FuncS
-
- Species Reactivity: Human
- Type: Human IgG
- Application: ELISA, Inhib
- Human Anti-IL18RAP Recombinant Antibody (clone 3131); Fab fragment (PABJ-0032-F(E))
-
- Species Reactivity: Human
- Type: Human Fab
- Application: ELISA, Inhib
-
- Species Reactivity: Human
- Application: WB
- Human Anti-IL18RAP Recombinant Antibody (clone 3131); scFv Fragment (PABJ-0032-S(P))
-
- Species Reactivity: Human
- Type: Human scFv
- Application: ELISA, Inhib
- Mouse Anti-IL18RAP Recombinant Antibody (clone CBL120) (NEUT-1253CQ)
-
- Species Reactivity: Human
- Type: Mouse IgG1
- Application: Neut, WB
- Mouse Anti-IL18RAP Recombinant Antibody (clone 10D34) (NEUT-1252CQ)
-
- Species Reactivity: Human
- Type: Mouse IgG1
- Application: Neut, WB
- Mouse Anti-IL18RAP Recombinant Antibody (clone CBL328) (NEUT-1251CQ)
-
- Species Reactivity: Human
- Type: Mouse IgG1
- Application: Neut, WB
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For Research Use Only. Not For Clinical Use.