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    IL3RA

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    Anti-IL3RA Products

    • IL3-PE immunotoxin (AGTO-L009E)
      • Species Reactivity: Human
      • Application: Cytotoxicity assay, Functional assay
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    • IL-3-DT immunotoxin (AGTO-G044D)
      • Species Reactivity: Human
      • Application: Cytotoxicity assay, Function study
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    • IL-3-PE immunotoxin (AGTO-G044E)
      • Species Reactivity: Human
      • Application: Cytotoxicity assay, Function study
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    More Infomation

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    For Research Use Only. Not For Clinical Use.


    The protein encoded by this gene is an interleukin 3 specific subunit of a heterodimeric cytokine receptor. The receptor is comprised of a ligand specific alpha subunit and a signal transducing beta subunit shared by the receptors for interleukin 3 (IL3), colony stimulating factor 2 (CSF2/GM-CSF), and interleukin 5 (IL5). The binding of this protein to IL3 depends on the beta subunit. The beta subunit is activated by the ligand binding, and is required for the biological activities of IL3. This gene and the gene encoding the colony stimulating factor 2 receptor alpha chain (CSF2RA) form a cytokine receptor gene cluster in a X-Y pseudoautosomal region on chromosomes X or Y. Alternatively spliced transcript variants encoding distinct isoforms have been found. [provided by RefSeq, Jun 2012]
    Protein class

    CD markers, FDA approved drug targets

    Predicted location

    Intracellular, Membrane (different isoforms)

    Single cell type specificity

    Cell type enhanced (dendritic cells, Endothelial cells, Adipocytes, monocytes, Langerhans cells)

    Immune cell specificity

    Immune cell enriched (basophil)

    Cell line specificity

    Cell line enhanced (HDLM-2, NB-4, RPMI-8226)

    Interaction

    Heterodimer of an alpha and a beta subunit. The beta subunit is common to the IL3, IL5 and GM-CSF receptors.

    Molecular function

    Receptor

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