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Il4

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The protein encoded by this gene is a pleiotropic cytokine produced by activated T cells. This cytokine is a ligand for interleukin 4 receptor. The interleukin 4 receptor also binds to IL13, which may contribute to many overlapping functions of this cytokine and IL13. STAT6, a signal transducer and activator of transcription, has been shown to play a central role in mediating the immune regulatory signal of this cytokine. This gene, IL3, IL5, IL13, and CSF2 form a cytokine gene cluster on chromosome 5q, with this gene particularly close to IL13. This gene, IL13 and IL5 are found to be regulated coordinately by several long-range regulatory elements in an over 120 kilobase range on the chromosome. Two alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]

Derivation:
Humanized
Species Reactivity:
Human
Type:
Antibody
Targets:
IL4 & IL13
Type:
TandAb
Application:
FuncS, Promising therapeutic agent
Application:
ELISA, FC
Type:
Human antibody
Application:
ELISA, FC
Application:
ELISA, FC
Type:
Human antibody
Application:
ELISA, FC
Species Reactivity:
Human
Type:
Mouse antibody
Application:
ELISA
Species Reactivity:
Canine
Type:
IgG1
Application:
Neut
Species Reactivity:
Feline
Type:
IgG2a
Application:
WB, ELISA(Cap), Neut
Species Reactivity:
Human
Type:
IgG1, κ
Application:
ELISA, Neut, WB
Species Reactivity:
Human
Type:
IgG
Application:
Neut
Species Reactivity:
Human
Type:
IgG1
Application:
BL, ELISA, IHC, WB
Species Reactivity:
Human
Type:
IgG1
Application:
ICC/IF, Neut, WB
Species Reactivity:
Human
Type:
IgG1
Application:
IHC-Fr, ELISA, ELISpot, Neut
Species Reactivity:
Human, Chimpanzee, Baboon, Cynomolgus, Rhesus
Type:
IgG1, κ
Application:
ELISA(Cap), ELISpot, Neut, ICFC, IHC, IP
Species Reactivity:
Human
Type:
IgG1
Application:
FC, ICC/IF, Neut, WB
Species Reactivity:
Human
Type:
IgG1
Application:
Neut, WB, IHC
Species Reactivity:
Human
Type:
IgG1
Application:
WB, ICC, Neut
Species Reactivity:
Rat
Type:
IgG1
Application:
WB, Neut
Species Reactivity:
Human
Type:
IgG2b
Application:
WB, Neut
Species Reactivity:
Human
Type:
IgG1, κ
Application:
ELISA, FC, IF, Neut, WB
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