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Neurofilaments are type IV intermediate filament heteropolymers composed of light, medium, and heavy chains. Neurofilaments comprise the axoskeleton and they functionally maintain the neuronal caliber. They may also play a role in intracellular transport to axons and dendrites. This gene is a member of the intermediate filament family and is involved in the morphogenesis of neurons.
Predicted location

Intracellular

Single cell type specificity

Group enriched (Bipolar cells, Rod photoreceptor cells, Horizontal cells, Early spermatids, Inhibitory neurons, Excitatory neurons, Late spermatids, Cone photoreceptor cells, Spermatocytes)

Immune cell specificity

Not detected in immune cells

Cell line specificity

Cell line enhanced (NTERA-2, SCLC-21H, SH-SY5Y, SiHa)

Interaction

Forms homodimers (in vitro) (By similarity). Forms heterodimers with NEFL, NEFM or NEFH (in vitro) (By similarity).

Molecular function

Developmental protein

More Types Infomation

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For Research Use Only. Not For Clinical Use.

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