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INSC
In Drosophila, neuroblasts divide asymmetrically into another neuroblast at the apical side and a smaller ganglion mother cell on the basal side. Cell polarization is precisely regulated by 2 apically localized multiprotein signaling complexes that are tethered by Inscuteable, which regulates their apical localization.
Predicted location
Intracellular
Single cell type specificity
Cell type enhanced (Pancreatic endocrine cells, Proximal tubular cells, Oligodendrocyte precursor cells, Early spermatids, Distal tubular cells, Exocrine glandular cells)
Immune cell specificity
Not detected in immune cells
Cell line specificity
Cell line enhanced (ASC TERT1, hTERT-HME1, Karpas-707, LHCN-M2, TIME)
Interaction
Interacts with ALS2CR19/PAR3B and F2RL2/PAR3 (PubMed:16458856). Interacts with GPSM1/AGS3 and GPSM2/LGN (via TPR repeat region) (PubMed:16458856, PubMed:22074847). Identified in a complex with GPSM2 and F2RL2 (PubMed:16458856).
Molecular function
Developmental protein
More Types Infomation
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- Derivation: Phage display library
- Species Reactivity: Human
- Type: Rabbit IgG
- Application: WB
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For Research Use Only. Not For Clinical Use.