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ITGA11

This gene encodes an alpha integrin. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This protein contains an I domain, is expressed in muscle tissue, dimerizes with beta 1 integrin in vitro, and appears to bind collagen in this form. Therefore, the protein may be involved in attaching muscle tissue to the extracellular matrix. Alternative transcriptional splice variants have been found for this gene, but their biological validity is not determined.
Predicted location

Membrane

Single cell type specificity

Cell type enhanced (Fibroblasts, Sertoli cells, Microglial cells, Cardiomyocytes, Peritubular cells, Excitatory neurons)

Immune cell specificity

Not detected in immune cells

Cell line specificity

Group enriched (fHDF/TERT166, hTERT-RPE1, U-138 MG, WM-115)

Interaction

Heterodimer of an alpha and a beta subunit. Alpha-11 associates with beta-1. Interacts with RAB21.

Molecular function

Integrin, Receptor

More Types Infomation

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For Research Use Only. Not For Clinical Use.

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