Disease related genes, Human disease related genes
Membrane
Cell type enhanced (Gastric mucus-secreting cells, Early spermatids, Late spermatids)
Not detected in immune cells
Cell line enhanced (Karpas-707, SCLC-21H)
Interacts with KCNB1 (By similarity). Associates with KCNH2/ERG1 (PubMed:10219239). May associate with KCNQ2 and KCNQ3 (PubMed:11034315,). Associates with HCN1 and probably HCN2. Heteromultimer with KCNC2. Interacts with KCNC2 (By similarity). Interacts with KCNQ1; forms a heterooligomer complex that targets to the membrane raft and leading to currents with an apparently instantaneous activation, a rapid deactivation process and a linear current-voltage relationship and decreases the amplitude of the outward current (PubMed:11101505, PubMed:20533308).
Ion channel, Potassium channel, Voltage-gated channel
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For Research Use Only. Not For Clinical Use.